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Target intelligence / Profile preview
Plasminogen-like protein B (PLGLB1)
- Target
- PLGLB1
- Molecular classification
- Other, Secreted plasma protein, PAN/APPLE-like domain
01
Overview
Plasminogen-like protein B is a secreted plasma protein encoded by the PLGLB1 gene. It exhibits similarity to the N-terminal activation peptide of plasminogen and can bind lysine residues on plasminogen's kringle domains, potentially modulating plasminogen activity and extracellular matrix remodeling. Expression of PLGLB1 is variable between tissues and is upregulated in some cancers. Its clinical role is unclear, and there are no drugs that directly interact with this target. The protein is not considered an enzyme, receptor, or transporter, but is grouped among plasma proteins with structural homology to plasminogen.
- Other names
- PLGLPLGP1PRGBPRP-Bplasminogen-related protein Bplasminogen like B1
02
Biological functions
May bind noncovalently to lysine binding sites in plasminogen's kringle domainsSuggested to interfere with fibrin or alpha-2-antiplasmin binding to plasminogenMay localize activity important for extracellular matrix destructionExpression varies among tissues and increases in cancer tissues
03
Disease associations
Cancer (expression increased in some tumor tissues)Localized chondrosarcomaAcute endophthalmitis
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