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Target intelligence / Profile preview
Plasmodium Antigen
- Molecular classification
- Protein, Glycoprotein
01
Overview
Plasmodium antigens are proteins or glycoproteins expressed by parasites of the genus *Plasmodium*, responsible for malaria. They mediate host cell invasion, immune evasion, and transmission. Key examples include HRP2, pLDH, AMA1, CSP, MSPs, and Pfs230/Pfs48/45. They serve as diagnostic markers and vaccine targets. Polymorphism presents a significant challenge for vaccine development.
02
Mechanism of action
Antibody-mediated neutralization; blocking parasite development; preventing transmission
03
Biological functions
Host cell invasionImmune evasionMetabolismTransmission
04
Disease associations
MalariaInfection
05
Safety considerations
Antigenic variation/polymorphism leading to immune evasionPotential for incomplete protection with single-antigen vaccinesOff-target effects of immune responses
06
Interacting drugs
RTS,S/AS01 (vaccine)
1 more in the full profile.
07
Biomarkers
HRP2pLDH
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