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Target intelligence / Profile preview
Plasmodium falciparum 6-phosphogluconate dehydrogenase (6PGD)
- Target
- 6PGD
- Molecular classification
- Enzyme
01
Overview
Plasmodium falciparum 6-phosphogluconate dehydrogenase (6PGD) is an enzyme involved in the pentose phosphate pathway, catalyzing the conversion of 6-phosphogluconate to ribulose 5-phosphate. This process generates NADPH, which is essential for antioxidant defense and redox regulation, and ribose 5-phosphate, necessary for DNA and RNA synthesis in the rapidly growing parasite. As such, it is considered an attractive target for antimalarial drug development.
- Other names
- Pf6PGD
02
Mechanism of action
Inhibiting 6PGD disrupts the pentose phosphate pathway, impacting NADPH production and ribose 5-phosphate synthesis, which are crucial for parasite survival and proliferation.
03
Biological functions
Antioxidant defenseRedox regulationDNA synthesisRNA synthesis
04
Disease associations
MalariaInfection
05
Safety considerations
The safety concerns are related to the specificity of drugs targeting this enzyme, as they must not significantly affect the human version of the enzyme or other related pathways.
06
Interacting drugs
Currently, specific interacting drugs are under investigation, such as those identified through pharmacophore-based virtual screening.
07
Biomarkers
Specific biomarkers for this target are not detailed in the literature yet.
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