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Target intelligence / Profile preview
Plasmodium falciparum 80S Ribosome (Pf80S)
- Target
- Pf80S
- Molecular classification
- Ribosome
01
Overview
The Plasmodium falciparum 80S ribosome (Pf80S) is the cytoplasmic ribosome of the malaria parasite P. falciparum, responsible for protein synthesis within the parasite. As a eukaryotic ribosome, it consists of two subunits: the small 40S and large 60S subunits. The Pf80S ribosome is structurally distinct from its human counterpart, particularly in its rRNA expansion segments and certain protein extensions, making it an attractive target for antimalarial drug development.
02
Mechanism of action
Inhibition of protein synthesis
03
Biological functions
mRNA-directed protein synthesisTranslation
04
Disease associations
Infection (Malaria)
05
Safety considerations
Potential off-target effects due to similarities with human ribosomes
06
Interacting drugs
Emetine
1 more in the full profile.
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