Plasmodium falciparum acyl-CoA synthetase 11 (PfACS11)

Plasmodium falciparum acyl-CoA synthetase 11 (PfACS11) is an enzyme of the acyl-CoA synthetase family involved in lipid metabolism in the malaria parasite. While not essential for growth in asexual blood stages in vitro, PfACS11 appears to play a significant role in mediating resistance to structurally diverse antimalarial compounds. Mutations in the PfACS11 gene are found in parasites that have acquired low-level resistance to specific antimalarial drugs, likely by decreasing protein stability or altering function. Therefore, while PfACS11 is not a primary drug target, it acts as an important mediator of drug resistance and is relevant in the context of surveillance for emerging antimalarial resistance.

For interacting drugs: PfACS11 is not the direct target; mutations in its gene enable resistance, possibly by altering protein stability or function. It acts as a resistance mediator rather than a direct point of compound inhibition.