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Plasmodium falciparum ATPase 4 (None)
- Target
- None
- Molecular classification
- P-type ATPase, Type IIC/Type 2D ATPase, Cation-translocating ATPase, Transporter
01
Overview
Plasmodium falciparum ATPase 4 (PfATP4) is an essential P-type cation translocating ATPase found in the plasma membrane of the malaria parasite Plasmodium falciparum. It functions as a Na+ efflux pump, maintaining low cytosolic Na+ concentrations critical for parasite viability and nutrient uptake. PfATP4 is a validated antimalarial drug target, with multiple classes of compounds inhibiting its function. Resistance to these drugs can arise from mutations in pfatp4, often with associated fitness costs.
- Other names
- PfATP4
02
Mechanism of action
Inhibition of PfATP4-mediated sodium efflux, leading to disruption of ion homeostasis and parasite death.
03
Biological functions
Sodium effluxMaintenance of low cytosolic Na+Ion homeostasisNutrient uptake support
04
Disease associations
InfectionMalaria
05
Safety considerations
Potential for drug resistance development through mutations in pfatp4.Fitness costs associated with drug resistance mutations impacting ion regulation.
06
Interacting drugs
Spiroindolones (e.g., cipargamin/KAE609)
2 more in the full profile.
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