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Plasmodium falciparum ATPase 4 protein (PfATP4)

Target: PfATP4
Molecular classification: Type II P-type ATPase, Type 2D (P2D) subfamily, Transporter

Overview

PfATP4 is an essential sodium efflux pump located at the plasma membrane of *P. falciparum*, crucial for maintaining ionic balance inside malaria parasites during their blood-stage lifecycle. Its unique role makes it highly "druggable," with several new-generation antimalarials targeting this protein directly—though emergence of resistant mutants remains an ongoing concern due to associated fitness costs limiting their spread under natural conditions.

Other names: PF3D7_1211900PFL0590c

Mechanism of action

Inhibition of PfATP4 activity leading to disruption of ionic homeostasis and parasite death.

Biological functions

Sodium extrusionMaintenance of low cytosolic Na+ concentrationIon homeostasis

Disease associations

InfectionMalaria

Safety considerations

Emergence of drug-resistant strains due to point mutations in PfATP4.Fitness costs associated with resistance mutations, potentially limiting their spread.Potential for off-target effects of inhibitors.

Interacting drugs

Cipargamin

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