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Plasmodium falciparum cyclic amine resistance locus (None)
- Target
- None
- Molecular classification
- Other
01
Overview
The Plasmodium falciparum cyclic amine resistance locus (PfCARL), also known as Pf3D7_0321900, encodes a conserved protein implicated in the parasite’s resistance to several classes of antimalarial compounds, most notably the imidazolopiperazines such as KAF156 and GNF179. The exact physiological function of PfCARL remains incompletely understood, but it is predicted to play a role in protein folding within the endoplasmic reticulum and is localized primarily to the cis-Golgi apparatus in both asexual and sexual blood stages of P. falciparum. Mutations in pfcarl confer resistance to multiple structurally unrelated antimalarial compounds, representing an important mechanism for multidrug resistance.
- Other names
- PfCARLPf3D7_0321900
02
Mechanism of action
Modulates levels or activity of small-molecule inhibitors that affect Golgi-related processes within the parasite cell.
03
Biological functions
Protein foldingProtein sortingMembrane trafficking
04
Disease associations
InfectionDrug resistance
05
Safety considerations
Emergence of drug resistanceMultidrug resistance
06
Interacting drugs
KAF156/Ganaplacide
2 more in the full profile.
07
Biomarkers
pfcarl mutations (L833I, L1073Q, L1136P, L830V, S1076N/I, V1103L, I1139K)
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