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Plasmodium falciparum cytoplasmic phenylalanyl-tRNA synthetase (PfcPheRS)

Target: PfcPheRS
Molecular classification: Enzyme, Aminoacyl-tRNA synthetase

Overview

Plasmodium falciparum cytoplasmic phenylalanyl-tRNA synthetase (PfcPheRS) is an essential enzyme in the malaria parasite, responsible for catalyzing the attachment of phenylalanine to its corresponding tRNA during protein synthesis. This process is critical for translating genetic information into functional proteins within the parasite. Inhibition of this enzyme by compounds like bicyclic azetidines disrupts protein synthesis and leads to parasite death, making it a validated antimalarial drug target.

Other names: PFA0480wPlasmodium falciparum phenylalanine--tRNA ligase alpha subunitcFRS

Mechanism of action

Inhibition of phenylalanyl-tRNA synthetase

Biological functions

Aminoacylation of tRNAProtein biosynthesisTranslation

Disease associations

InfectionMalaria

Interacting drugs

BRD3444

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