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Plasmodium falciparum Cytoplasmic Ribosome (Pf80S)

Target: Pf80S
Molecular classification: Ribosome

Overview

The cytoplasmic ribosome of Plasmodium falciparum (Pf80S) is the primary molecular machine responsible for protein synthesis in the malaria parasite. It is a eukaryotic 80S ribosome, composed of a small (40S) and large (60S) subunit, each containing ribosomal RNA (rRNA) and numerous proteins. The Pf80S ribosome exhibits unique structural features compared to human and other eukaryotic ribosomes, which are relevant for both its biological function and as a drug target.

Other names: Pf80S RibosomeP. falciparum 80S Ribosome

Mechanism of action

Inhibition of protein synthesis

Biological functions

Protein synthesisTranslation

Disease associations

Malaria

Safety considerations

Potential for off-target effects on human ribosomes

Interacting drugs

Emetine

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