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Target intelligence / Profile preview
Plasmodium falciparum Gamete Surface Antigen Pfs230 (Pfs230)
- Target
- Pfs230
- Molecular classification
- Surface Antigen, Six-cysteine protein
01
Overview
Pfs230 is a large, multi-domain protein expressed on the surface of gametocytes and gametes of *Plasmodium falciparum*. It is essential for sexual reproduction within the mosquito vector and is a leading target for transmission-blocking vaccines (TBVs). Antibodies against Pfs230 can block parasite development inside mosquitoes, preventing further transmission to humans. It forms a membrane-bound complex with Pfs48/45.
- Other names
- Gametocyte surface protein P230P230
02
Mechanism of action
Antibody-mediated complement-dependent lysis of parasites; Interference with fertilization
03
Biological functions
Male/female gamete fusionMale gamete exflagellationHost erythrocyte interactionFertilization
04
Disease associations
MalariaInfection
05
Safety considerations
Polymorphism may impact vaccine efficacy
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