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Plasmodium falciparum Haem Detoxification Pathway
- Molecular classification
- Metabolic pathway
01
Overview
The Plasmodium falciparum haem detoxification pathway is a critical biological process that enables the malaria parasite to survive within human red blood cells. During its intraerythrocytic stage, the parasite digests host hemoglobin in an acidic digestive vacuole (DV), releasing large amounts of free haem (ferriprotoporphyrin IX, Fe(III)PPIX). Free haem is highly toxic due to its ability to generate reactive oxygen species and disrupt cellular membranes. To avoid toxicity, *P. falciparum* rapidly converts free haem into an inert crystalline pigment called hemozoin. Several antimalarial drugs act by disrupting this pathway: Chloroquine and Artemisinin-based drugs.
02
Mechanism of action
Inhibition of hemozoin formation, leading to accumulation of toxic free haem
03
Biological functions
Haem detoxificationHemozoin formationParasite survival
04
Disease associations
Malaria
05
Safety considerations
Drug resistanceOff-target effects
06
Interacting drugs
Chloroquine
1 more in the full profile.
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