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Target intelligence / Profile preview
Plasmodium falciparum Liver Stage Antigen 3 (LSA-3)
- Target
- LSA-3
- Molecular classification
- Antigen
01
Overview
Liver stage antigen 3 (LSA-3) is a highly conserved protein expressed by Plasmodium falciparum during the pre-erythrocytic (liver) stage of its lifecycle. It is a promising candidate for malaria vaccine development due to its strong immunogenicity and association with protective immune responses. It elicits strong T-cell and B-cell responses and is found on the surface of sporozoites and localized within the parasitophorous vacuole membrane (PVM) inside infected hepatocytes. Recombinant LSA‑3 has shown utility for early serodiagnosis of P. falciparum infection.
02
Mechanism of action
LSA-3 is targeted by antibodies and T-cells, leading to parasite clearance and protection from infection.
03
Biological functions
Immune responseParasite survival in liver stage
04
Disease associations
InfectionMalaria
05
Safety considerations
Potential for immune evasion through antigenic variation.
06
Biomarkers
Anti-LSA-3 antibodies as correlate of protection
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