Plasmodium falciparum Membrane (via Reactive Oxygen Species) (Pf Membrane (ROS))

The Plasmodium falciparum membrane, specifically during the erythrocytic stage, is a crucial target for antimalarial strategies utilizing reactive oxygen species (ROS). ROS, generated by antimalarial drugs like artemisinins or by the host immune response, induce oxidative damage to membrane lipids and proteins, leading to increased permeability, mitochondrial dysfunction, and ultimately parasite death. The parasite's limited antioxidant defenses, particularly the absence of catalase and glutathione peroxidase, make it vulnerable to oxidative stress. PfATP6/SERCA is a proposed molecular target.

Other names

P. falciparum Plasma MembraneP. falciparum Organellar MembranesP. falciparum Membrane Lipid BilayerP. falciparum Membrane Proteins

Lipid peroxidation, protein alkylation, mitochondrial depolarization, and increased membrane permeability induced by reactive oxygen species.