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Plasmodium falciparum Purine Nucleoside Phosphorylase (PfPNP)

Target: PfPNP
Molecular classification: Enzyme

Overview

Plasmodium falciparum purine nucleoside phosphorylase (PfPNP) is a crucial enzyme in the purine salvage pathway of the malaria parasite P. falciparum. The parasite relies on salvaging purines from its host, making PfPNP essential for survival. It catalyzes the reversible phosphorolysis of purine nucleosides, converting them into bases and ribose 1-phosphate. As an essential enzyme absent from host red blood cells, PfPNP is an attractive antimalarial drug target.

Other names: Purine nucleoside phosphorylase

Mechanism of action

Inhibition of purine salvage, leading to purine starvation in the parasite.

Biological functions

Purine salvage pathwayNucleoside catabolism

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Infection

Safety considerations

Potential for resistance development

Interacting drugs

DADMe-Immucillin-G

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