Plasmolipin (PLLP)

Plasmolipin is a highly hydrophobic transmembrane protein encoded by the *PLLP* gene on chromosome 16, primarily localized in the myelin sheath and plasma membrane of nervous system cells[1][3]. It contains four transmembrane domains forming the MARVEL domain, facilitating membrane organization, vesicle trafficking, and myelin maintenance[1]. Plasmolipin is important in nervous system development, intracellular protein sorting, and is implicated in myelin assembly, Notch signaling, and the formation of lipid rafts[1][7]. Changes in plasmolipin expression have been associated with neurodegenerative diseases (such as Alzheimer’s and schizophrenia), certain cancers, and possibly metabolic disorders like type 2 diabetes[1]. While it shares some features with tetraspanins and other myelin proteins (e.g., MAL, PLP), it is not an ion channel or classical receptor and currently lacks direct therapeutic targeting by drugs[1][7].

Other names

Plasma membrane proteolipidPMLPTM4SF11Plasma membrane proteolipid (plasmolipin)Transmembrane 4 superfamily member 11 (plasmolipin)