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Target intelligence / Profile preview
Platelet Activating Factor (PAF)
- Target
- PAF
- Molecular classification
- Phospholipid mediator, Alkyl phosphoglyceride, Lipid mediator
01
Overview
Platelet-activating factor (PAF) is a potent phospholipid mediator involved in numerous physiological and pathological processes, particularly those related to inflammation, thrombosis, and immune responses. It acts as both an intercellular messenger and intracellular signal transducer, playing critical roles in cardiovascular physiology/pathophysiology and contributing to diseases like atherosclerosis and asthma. PAF exerts its effects by binding to the Platelet Activating Factor Receptor (PAFR).
- Other names
- PAF-acetherAGEPCAcetyl-glyceryl-ether-phosphorylcholine
02
Mechanism of action
PAF exerts its effects by binding to the Platelet Activating Factor Receptor (PAFR), a G-protein coupled receptor, leading to downstream signaling cascades.
03
Biological functions
Platelet aggregationLeukocyte chemotaxisIncreased vascular permeabilityOxidative burst in phagocytesArachidonic acid metabolism modulationBlood pressure regulationAngiogenesis
04
Disease associations
InflammationAnaphylaxisAtherosclerosisCardiovascular diseaseAsthmaMyocardial ischemia-reperfusion injuryShock syndromes
05
Safety considerations
Excessive PAF activity is implicated in various inflammatory and cardiovascular diseases.Therapeutic challenges exist in selectively targeting PAF-related pathways without causing broad immunosuppression or affecting essential physiological functions.
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