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Target intelligence / Profile preview
Platelet-activating factor acetylhydrolase 1b catalytic subunit 3 (PAFAH1B3)
- Target
- PAFAH1B3
- Molecular classification
- Enzyme, Hydrolase
01
Overview
Platelet-activating factor acetylhydrolase 1b catalytic subunit 3 (PAFAH1B3) is an enzyme that removes an acetyl group from the glycerol backbone of platelet-activating factor (PAF) and related lipids, terminating PAF signaling. It is a catalytic subunit (alpha1) of the cytosolic PAF acetylhydrolase isoform 1B complex, which also contains alpha2 (PAFAH1B2) and a regulatory beta subunit (PAFAH1B1). This complex is important for normal brain development. Alterations, including chromosomal translocations involving PAFAH1B3, have been linked to neurological disorders such as cognitive disability and ataxia. The protein displays hydrolase activity and is involved in lipid metabolism pathways.
- Other names
- Platelet-activating factor acetylhydrolase IB subunit gammaPAFAHGPAF-AH1b alpha 1 subunitPAF acetylhydrolase 29 kDa subunitPAF-AH 29 kDa subunitPAF-AH subunit gammaepididymis secretory sperm binding proteinplatelet-activating factor acetylhydrolase 1b catalytic subunit 3PAF-AH alpha 1PAFAH subunit gammaEC 3.1.1.47
02
Biological functions
Hydrolysis of platelet-activating factor (PAF)Lipid metabolismRegulation of PAF signalingRole in brain development
03
Disease associations
Intellectual developmental disorderSpastic paraplegiaCognitive disabilityAtaxiaBrain atrophyPotential cancer driver
04
Safety considerations
No specific therapeutic safety data known. Experimental disruption associated with neurological syndromes (e.g., cognitive disability, ataxia) due to chromosomal translocation.
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