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Platelet Activating Factor Synthetase
- Molecular classification
- Enzyme, Acetyltransferase, Lipid Metabolism Enzyme
01
Overview
Platelet activating factor synthetase refers to the family of enzymes responsible for the biosynthesis of platelet-activating factor (PAF), a potent lipid mediator involved in inflammation, immune responses, and various physiological processes. The main enzymatic activity associated with this process is acetyl-CoA:lyso-PAF acetyltransferase (also known as LPCAT2 or LPLAT9), which transfers an acetyl group from acetyl-CoA to 1-O-alkyl-sn-glycerol-3-phosphocholine (lyso-PAF) at the sn-2 position. Dysregulation or overproduction can contribute to chronic inflammatory diseases including cardiovascular disease and asthma due to excessive pro-inflammatory signaling.
- Other names
- PAF SynthetaseAcetyl-CoA:lyso-PAF acetyltransferaseLPCAT2LPLAT9
02
Mechanism of action
Inhibition of PAF synthesis
03
Biological functions
Lipid biosynthesisPAF synthesisInflammation modulationImmune response
04
Disease associations
InflammationCardiovascular diseaseAsthmaChronic inflammatory diseases
05
Safety considerations
Potential for immunosuppressionOff-target effects due to structural similarity to other lipid-modifying enzymes
06
Interacting drugs
PAF synthetase inhibitors
1 more in the full profile.
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