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Target intelligence / Profile preview
Platelet cyclooxygenase-1 (COX-1)
- Target
- COX-1
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Platelet cyclooxygenase-1 (COX-1) is an enzyme predominantly expressed in platelets, where it plays a central role in the biosynthesis of thromboxane A2 (TXA2), a potent mediator of platelet aggregation and vasoconstriction. It catalyzes the conversion of arachidonic acid into prostaglandin H2 (PGH2), which is then converted into TXA2. Aspirin irreversibly inhibits COX-1, reducing platelet aggregation and providing antithrombotic effects. Inadequate inhibition or resistance to aspirin can occur, leading to persistent thromboxane generation. COX-1 also contributes to inflammation-related vascular diseases.
- Other names
- Prostaglandin-endoperoxide synthase 1PTGS1
02
Mechanism of action
Irreversible inhibition of cyclooxygenase activity by acetylation of Serine 529, preventing thromboxane A2 synthesis.
03
Biological functions
Prostaglandin synthesisThromboxane A2 synthesisPlatelet aggregationVasoconstriction
04
Disease associations
Cardiovascular diseaseThrombosisInflammationVascular diseases
05
Safety considerations
Increased bleeding riskAspirin resistanceGastrointestinal bleeding
06
Interacting drugs
Aspirin
07
Biomarkers
Thromboxane B2 levels (surrogate marker for TXA2 production)Platelet aggregation assays
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