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Platelet-derived Growth Factor (None)
- Target
- None
- Molecular classification
- Growth Factor, Cytokine, Secreted Protein
01
Overview
Platelet-derived growth factor (PDGF) is a family of dimeric glycoprotein growth factors that regulate cell growth, division, and migration, particularly in mesenchymal-origin cells. PDGF is crucial for angiogenesis, wound healing, embryonic development, and tissue repair. Aberrant PDGF/PDGFR signaling is implicated in cancer, fibrosis, and atherosclerosis. Recombinant human PDGF is used therapeutically to promote healing.
- Other names
- PDGFPDGF-AAPDGF-ABPDGF-BBPDGF-CCPDGF-DD
02
Mechanism of action
Recombinant human PDGF promotes cell proliferation and migration by binding to and activating PDGFRs. PDGFR inhibitors block the tyrosine kinase activity of PDGFRs, inhibiting downstream signaling pathways that drive cell proliferation and angiogenesis.
03
Biological functions
MitogenesisChemotaxisCell proliferationCell migrationAngiogenesisWound healingEmbryonic developmentTissue repair
04
Disease associations
CancerFibrotic diseasesAtherosclerosisChronic ulcersOcular surface diseaseBone regeneration issues
05
Safety considerations
Potential for promoting tumor growthExacerbation of fibrotic diseasesOff-target effects of PDGFR inhibitors
06
Interacting drugs
Recombinant human platelet-derived growth factor
1 more in the full profile.
07
Biomarkers
PDGF expression levels in tumor tissuePDGFR phosphorylation statusCirculating PDGF levels
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