Platelet-derived growth factor subunit A (PDGFA)

Platelet-derived growth factor subunit A (PDGFA) is a secreted **growth factor** belonging to the PDGF/VEGF protein family, which functions as a potent mitogen for cells of mesenchymal origin such as fibroblasts, smooth muscle cells, and glial cells[2][3][4][7][8]. It can form homodimers (PDGF-AA) or heterodimers with PDGF subunit B (PDGF-AB), with all PDGF dimers acting through binding and activating the **PDGF receptor tyrosine kinases** (primarily PDGFRα and PDGFRβ)[1][4][7]. PDGFA is crucial for diverse processes in **embryonic development**, including alveolar formation in the lung, gastrointestinal tract development, and oligodendrocyte/myelination in the nervous system[3][4][7]. It has important roles in **cell proliferation, migration, wound healing**, and tissue repair, and dysregulation is implicated in various **cancers, fibrotic diseases, and cardiovascular pathologies**[4][8]. While not itself the target of approved drugs, its pathways are targeted for inhibition in oncology and for stimulation in regenerative medicine (e.g., growth factor gels for chronic wounds)[3][4]. Overactivity raises potential **oncogenic and pro-fibrotic safety concerns**.

Other names

PDGF-APlatelet-derived growth factor A chainPlatelet-derived growth factor alpha chainPlatelet-derived growth factor alpha polypeptidePDGF 1PDGF subunit APDGF1Platelet-derived growth factor A-chain

Ligand for PDGF receptor tyrosine kinases (mainly PDGFRα and PDGFRβ), activating downstream signaling pathways leading to proliferation, migration, and survival of target cells