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Platelet-derived Growth Factor Pathway (PDGF Pathway)
- Target
- PDGF Pathway
- Molecular classification
- Growth factors, Receptor tyrosine kinases, Ligands, Receptors
01
Overview
The Platelet-derived growth factor (PDGF) pathway is comprised of a family of secreted, dimeric glycoproteins and their associated cell surface receptors that play critical roles in regulating cell growth, proliferation, migration, and survival. The pathway is essential for embryonic development, tissue repair, and implicated in various diseases including cancer. PDGF ligands bind to PDGF receptors (PDGFRs), receptor tyrosine kinases, activating downstream signaling cascades.
- Other names
- PDGFPDGF Signaling Pathway
02
Mechanism of action
Ligand binding induces receptor dimerization and autophosphorylation, activating downstream signaling cascades that regulate gene expression affecting proliferation, cell cycle, migration, and cytoskeletal rearrangement.
03
Biological functions
Cell growthCell proliferationCell migrationCell differentiationDevelopmentAngiogenesisWound healingChemotaxis
04
Disease associations
CancerGliomasSarcomasLeukemiasFibrosisVessel disordersTumor stroma recruitment
05
Safety considerations
Off-target effects of inhibitorsDevelopment of resistance to inhibitorsPotential for promoting angiogenesis in certain contexts
06
Interacting drugs
PDGF inhibitors (e.g., Imatinib, Sunitinib, Sorafenib, Pazopanib)
1 more in the full profile.
07
Biomarkers
PDGFRA expressionPDGFRB expression
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