Platelet-Derived Growth Factor Receptor (PDGFR)

Platelet-derived growth factor receptors (PDGFRs) are cell surface receptor tyrosine kinases that play a central role in regulating cell proliferation, differentiation, growth, and development. They are especially important in connective tissue cells such as fibroblasts and smooth muscle cells. There are two main types: PDGFRα and PDGFRβ. Ligand binding induces receptor dimerization and autophosphorylation, triggering downstream signaling cascades involved in cell proliferation, migration, survival, and differentiation. Aberrant activation or overexpression/mutation of PDGFRs has been implicated in various diseases including cancers, fibrotic disorders, and atherosclerosis, making them important therapeutic targets.

Other names

PDGFR alphaPDGFR betaPDGFRAPDGFRB

Tyrosine kinase inhibition (for targeted therapies)