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Target intelligence / Profile preview
Platelet-derived Growth Factor Receptor Alpha (PDGFRA)
- Target
- PDGFRA
- Molecular classification
- Receptor Tyrosine Kinase, Receptor
01
Overview
Platelet-derived growth factor receptor alpha (PDGFRA) is a receptor tyrosine kinase that plays a crucial role in cell growth, survival, and differentiation. It is activated by binding to PDGF ligands, leading to autophosphorylation and downstream signaling. Dysregulation of PDGFRA is implicated in cancer and fibrosis, making it a therapeutic target. Targeted therapies like imatinib, block its kinase activity.
- Other names
- CD140aPlatelet-Derived Growth Factor Receptor Alpha
02
Mechanism of action
Kinase inhibition
03
Biological functions
Signal transductionCell proliferationCell survivalDifferentiationMigrationWound healingEmbryonic development
04
Disease associations
CancerGastrointestinal stromal tumors (GISTs)Hypereosinophilic syndromeFibrosis
05
Safety considerations
Potential for off-target effects of kinase inhibitors
06
Interacting drugs
07
Biomarkers
PDGFRA mutations in GISTs
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