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Target intelligence / Profile preview
Platelet-derived growth factor receptor alpha polypeptide (PDGFRA)
- Target
- PDGFRA
- Molecular classification
- Receptor tyrosine kinase, RTK, Cell surface receptor
01
Overview
Platelet-derived growth factor receptor alpha polypeptide (PDGFRA) is a receptor tyrosine kinase that binds to PDGF ligands and regulates cell proliferation, survival, and differentiation. It plays a critical role in embryonic development and is implicated in various cancers and fibrotic diseases. Activation of PDGFRA leads to autophosphorylation and activation of downstream signaling pathways such as PI3K/AKT and MAPK. Mutations or aberrant activation of PDGFRA are linked to diseases like gastrointestinal stromal tumors (GISTs) and idiopathic hypereosinophilic syndrome.
- Other names
- CD140aCD140AGAS9PDGFR-alphaPDGFR2PGFRA_HUMANplatelet-derived growth factor receptor 2
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Cell proliferationCell survivalCellular differentiationEmbryonic developmentSignal transductionWound healing
04
Disease associations
Gastrointestinal stromal tumors (GISTs)Idiopathic hypereosinophilic syndromeCancerTumor progressionFibrosis
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