Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Platelet-derived growth factor receptor alpha subunit
- Molecular classification
- Receptor, Receptor Tyrosine Kinase, Class III Receptor Tyrosine Kinase
01
Overview
Platelet-derived growth factor receptor alpha (PDGFRα), also known as CD140a, is a cell surface receptor tyrosine kinase. It is a critical regulator of cellular growth, differentiation, and development, particularly in mesodermal tissues. PDGFRα plays essential roles during embryogenesis and in maintaining tissue homeostasis. Ligand binding (PDGF-A, -B, -C) induces receptor dimerization and autophosphorylation, activating downstream signaling pathways like PI3K/AKT and MAPK. Mutations in PDGFRA are linked to GISTs and clonal hypereosinophilic syndromes, making it a clinically relevant target for therapies like imatinib.
- Other names
- PDGFRαCD140a
02
Mechanism of action
Tyrosine kinase inhibitor; inhibits the tyrosine kinase activity of PDGFRα, preventing receptor autophosphorylation and downstream signaling.
03
Biological functions
Cell growthCell differentiationEmbryonic developmentTissue maintenanceSignal transductionCell proliferationCell migrationCell survival
04
Disease associations
CancerGastrointestinal stromal tumors (GISTs)Clonal hypereosinophilic syndromesFibrotic diseasesAtherosclerosisNeoplasms involving mesenchymal origin
05
Safety considerations
Aberrant proliferation leading to tumor formation if negative feedback mechanisms are disrupted.
06
Interacting drugs
Beyond the preview
Go deeper on Platelet-derived growth factor receptor alpha subunit.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Platelet-derived growth factor receptor alpha subunit.