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Target intelligence / Profile preview
Platelet-derived Growth Factor Receptor Beta (PDGFRβ)
- Target
- PDGFRβ
- Molecular classification
- Receptor tyrosine kinase (RTK), Type III receptor tyrosine kinase family
01
Overview
Platelet-derived growth factor receptor beta (PDGFRβ) is a cell surface receptor encoded by the *PDGFRB* gene. It belongs to the type III receptor tyrosine kinase family and plays a critical role in cellular signaling, particularly in processes such as cell proliferation, migration, survival, and differentiation. It is essential for embryonic development, regulates pericyte recruitment, controls tissue homeostasis, and is involved in wound healing. Due to its central role in pathological proliferation/migration of vascular smooth muscle/fibroblasts/pericytes—and its involvement in certain cancers—PDGFRβ is a target for small molecule inhibitors used clinically.
- Other names
- PDGFRB
02
Mechanism of action
Inhibition of tyrosine kinase activity of PDGFRβ, blocking downstream signaling pathways.
03
Biological functions
Cell proliferationCell migrationCell survivalCell differentiationAngiogenesisHematopoiesisWound healingTissue homeostasis
04
Disease associations
Myeloproliferative neoplasmsLeukemiaAtherosclerosisFibrotic disorders5q-syndrome
05
Safety considerations
Overactivity implicated in malignancies and non-cancerous diseases.Potential progression to aggressive leukemia if untreated.
06
Interacting drugs
Small molecule inhibitors of PDGFRβ (specific names not provided in text)
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