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Target intelligence / Profile preview
Platelet-derived Growth Factor Receptor Type Beta (PDGFRβ)
- Target
- PDGFRβ
- Molecular classification
- Receptor, Receptor Tyrosine Kinase, Type III Receptor Tyrosine Kinase
01
Overview
Platelet-derived growth factor receptor beta (PDGFRβ) is a receptor tyrosine kinase that binds to PDGF-B and PDGF-D ligands. It plays a crucial role in regulating cellular processes such as proliferation, migration, survival, and differentiation. Aberrant PDGFRβ signaling is implicated in various diseases, including hematologic malignancies, making it a therapeutic target.
- Other names
- CD140bPDGF-R-betaPDGFR1beta-type platelet-derived growth factor receptor
02
Mechanism of action
Selective inhibition of PDGFRβ kinase activity.
03
Biological functions
Signal transductionCell proliferationCell migrationCell survivalCell differentiationAngiogenesisHematopoiesis
04
Disease associations
Hematologic malignanciesMyeloproliferative neoplasmsLeukemiaT-cell acute lymphoblastic leukemia/lymphoma (T‑ALL/T‑LBL)5q-syndrome
05
Safety considerations
Potential for off-target effectsDevelopment of resistance
06
Interacting drugs
CP‑673451
1 more in the full profile.
07
Biomarkers
Phosphorylated PDGFRβ levels
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