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Target intelligence / Profile preview
Platelet-derived Growth Factor Receptor Tyrosine Kinase Family (PDGFR Tyrosine Kinase Family)
- Target
- PDGFR Tyrosine Kinase Family
- Molecular classification
- Receptor Tyrosine Kinase, Type III RTK, Receptor
01
Overview
The platelet-derived growth factor receptor (PDGFR) tyrosine kinase family is a group of cell surface receptors that play a crucial role in cellular signaling, particularly in the regulation of cell growth, survival, and development. These receptors are part of the type III receptor tyrosine kinase (RTK) family and include two main isoforms: PDGFRα and PDGFRβ. Ligands include PDGF-A, PDGF-B, PDGF-C and PDGF-D, forming homo- or heterodimers that activate the receptors. Activation leads to autophosphorylation and downstream signaling, influencing cell proliferation, migration, and differentiation. Dysregulation is associated with diseases like cancer, atherosclerosis, and fibrotic conditions.
- Other names
- PDGFRPDGFR familyPlatelet-derived growth factor receptorType III receptor tyrosine kinases
02
Mechanism of action
Inhibition of receptor tyrosine kinase activity, blocking downstream signaling pathways.
03
Biological functions
Cell growthCell survivalCell developmentCell proliferationCell migrationCell differentiationEmbryonic developmentTissue homeostasisSignal transduction
04
Disease associations
CancerAtherosclerosisFibrotic diseasesMalignancies
05
Safety considerations
Excessive cell proliferationPotential for off-target effects due to structural similarity with other RTKs.
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