Target intelligence / Profile preview

Platelet-derived Growth Factor Signaling (None)

Target: None
Molecular classification: Signaling Pathway

Overview

Platelet-derived growth factor (PDGF) signaling is a critical pathway that regulates cell growth, division, migration, and survival. It plays essential roles in embryonic development, tissue repair, angiogenesis (formation of new blood vessels), and the pathogenesis of various diseases including cancer and fibrosis. The pathway is activated by PDGF ligands binding to PDGFR receptors, leading to receptor dimerization and activation of downstream signaling cascades such as PI3K/Akt, JAK/STAT, RAS/MAPK, and NF-κB.

Mechanism of action

Not applicable - signaling pathway

Biological functions

Cell proliferationCell migrationCell survivalCell differentiationEmbryonic developmentAngiogenesisWound healingInflammation response

Disease associations

CancerFibrosisVascular disorders

Interacting drugs

PDGFR inhibitors

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