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Target intelligence / Profile preview
Platelet-derived Growth Factor Subunit B (PDGF-B)
- Target
- PDGF-B
- Molecular classification
- Growth Factor, Cytokine, Secreted Protein
01
Overview
Platelet-derived growth factor subunit B (PDGF-B) is a potent mitogen that stimulates the proliferation and migration of cells of mesenchymal origin. It plays a crucial role in various biological processes, including embryonic development, wound healing, and angiogenesis. PDGF-B functions by binding to and activating tyrosine kinase receptors PDGFR-alpha and PDGFR-beta, initiating downstream signaling cascades that regulate cell growth, survival, and differentiation. Overexpression or mutations in PDGFB are implicated in diseases such as meningioma and dermatofibrosarcoma protuberans (DFSP).
- Other names
- PDGFBPDGF-BB
02
Mechanism of action
Binding to PDGFR-alpha and PDGFR-beta receptors, activating downstream signaling pathways (PI3K/Akt, MAPK, PLCγ)
03
Biological functions
Cell proliferationCell migrationCell survivalChemotaxisAngiogenesisWound healingEmbryonic development
04
Disease associations
CancerMeningiomaDermatofibrosarcoma protuberans (DFSP)FibrosisChronic wounds
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