Platelet-derived signaling molecules

Platelet-derived signaling molecules refer collectively to various factors secreted by activated platelets—including nucleotides (ADP, ATP), lipid mediators (thromboxane A2), amines (serotonin), proteins (growth factors, cytokines, chemokines)—that signal through specific receptors on platelets, endothelial cells, immune cells, and other target cells. These molecules play central roles in hemostasis, thrombosis, vascular repair, inflammation, and the pathogenesis of cardiovascular, neoplastic, infectious, and fibrotic diseases. They are frequent targets for therapy (e.g., antiplatelet agents in stroke and myocardial infarction). However, the phrase "platelet-derived signaling molecules" is not a precise, structured target name but an umbrella term encompassing heterogeneous entities.

Other names

Platelet agonistsPlatelet releasatesPlatelet granule contentsPlatelet-secreted factorsPlatelet-derived mediators

Inhibition of receptor binding (P2Y12, PAR1, GP IIb/IIIa, TxA2 receptor) Inhibition of ligand synthesis or function/release (Aspirin blocks TxA2 synthesis; PDGF inhibitors block receptor tyrosine kinase activity)