Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Platelet Endothelial Cell Adhesion Molecule‑1 (PECAM-1)
- Target
- PECAM-1
- Molecular classification
- Transmembrane glycoprotein, Immunoglobulin superfamily
01
Overview
CD31/PECAM‑1 is a key adhesion molecule highly expressed on tumor-associated endothelial cells. It plays central roles in angiogenesis, regulation of vascular permeability/barrier function during vessel remodeling, and control over immune cell trafficking into tissues—including tumors. Its expression makes it both a valuable biomarker for assessing tumor vasculature status and an attractive therapeutic target for strategies aimed at disrupting pathological angiogenesis or improving drug delivery within solid malignancies.
- Other names
- CD31
02
Mechanism of action
Antiangiogenic therapies; Enhancing drug delivery; Modulation of immune infiltration
03
Biological functions
AngiogenesisVascular remodelingLeukocyte transmigrationImmune modulationCell-cell adhesionSignal transduction
04
Disease associations
CancerInflammation
05
Biomarkers
Microvessel density (MVD)
Beyond the preview
Go deeper on Platelet Endothelial Cell Adhesion Molecule‑1 (PECAM-1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Platelet Endothelial Cell Adhesion Molecule‑1 (PECAM-1).