Target intelligence / Profile preview

Platelet Factor 3 (PF3)

Target: PF3
Molecular classification: Phospholipid, Cofactor

Overview

Platelet factor 3 (PF3) is a phospholipid component of the platelet membrane, primarily phosphatidylserine. Upon platelet activation, PF3 is exposed or released from the platelet surface and provides a catalytic surface necessary for the assembly of coagulation enzyme complexes, thereby facilitating thrombin formation and subsequent clot development. It is essential for normal hemostasis and represents an important diagnostic marker.

Biological functions

Blood coagulationThrombin generationHemostasis

Disease associations

Bleeding disordersThrombosisRenal failure

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