Target intelligence / Profile preview

Platelet Glycoprotein Ib Alpha Chain (GPIbα)

Target: GPIbα
Molecular classification: Receptor, Glycoprotein

Overview

Platelet glycoprotein Ib alpha chain (GPIbα, CD42b) is a critical component of the platelet surface membrane receptor complex involved in hemostasis and thrombosis. It mediates platelet adhesion to sites of vascular injury by binding von Willebrand factor (VWF) exposed at damaged vessel walls, initiating platelet tethering under high shear conditions and triggering downstream signaling cascades. Mutations or polymorphisms in GP1BA are associated with bleeding disorders.

Other names: CD42bGP1BABDPLT1BDPLT3DBPLT3GpIbAGpIbalphaVWDP

Mechanism of action

N/A

Biological functions

Platelet adhesionHemostasisThrombosisSignal transduction

Disease associations

Bernard-Soulier syndromePlatelet-type von Willebrand diseaseBleeding disorders

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