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Target intelligence / Profile preview
Platelet Glycoprotein Ib-IX-V Complex (GPIb-IX-V)
- Target
- GPIb-IX-V
- Molecular classification
- Receptor, Heterotetrameric complex, Type I transmembrane protein
01
Overview
The platelet glycoprotein Ib–IX–V complex (GPIb-IX-V) is a membrane receptor complex found exclusively on the surface of platelets and their precursor cells, megakaryocytes. It plays a central role in hemostasis by mediating platelet adhesion to sites of vascular injury. The complex consists of four distinct subunits: GPIbα, GPIbβ, GPIX, and GPV. Its primary function is to bind von Willebrand factor (VWF) exposed at sites of vascular injury under high shear stress conditions, triggering platelet arrest, activation, and aggregation. Deficiency or dysfunction leads to Bernard-Soulier syndrome. It is an attractive target for anti-thrombotic therapies.
- Other names
- Glycoprotein Ib-IX-VGPIb/IX/VCD42b/CD42a/CD42c/CD42d
02
Mechanism of action
Inhibition of platelet adhesion to von Willebrand factor
03
Biological functions
Platelet adhesionHemostasisMechanosensingSignal transductionPlatelet activationThrombus formationInteraction with coagulation factors
04
Disease associations
Bernard-Soulier syndromeThrombosisStrokeMyocardial infarctionInflammationMetastasisInfection
05
Safety considerations
Increased risk of bleedingThrombocytopenia
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