Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Platelet Glycoprotein Ib-IX-V Complex (GPIb-IX-V)
- Target
- GPIb-IX-V
- Molecular classification
- Receptor, Heterotetrameric complex, Type I transmembrane protein
01
Overview
The platelet glycoprotein Ib–IX–V complex (GPIb-IX-V) is a membrane receptor complex found exclusively on the surface of platelets and their precursor cells, megakaryocytes. It plays a central role in hemostasis by mediating platelet adhesion to sites of vascular injury. The complex consists of four distinct subunits: GPIbα, GPIbβ, GPIX, and GPV. Its primary function is to bind von Willebrand factor (VWF) exposed at sites of vascular injury under high shear stress conditions, triggering platelet arrest, activation, and aggregation. Deficiency or dysfunction leads to Bernard-Soulier syndrome. It is an attractive target for anti-thrombotic therapies.
- Other names
- Glycoprotein Ib-IX-VGPIb/IX/VCD42b/CD42a/CD42c/CD42d
02
Mechanism of action
Inhibition of platelet adhesion to von Willebrand factor
03
Biological functions
Platelet adhesionHemostasisMechanosensingSignal transductionPlatelet activationThrombus formationInteraction with coagulation factors
04
Disease associations
Bernard-Soulier syndromeThrombosisStrokeMyocardial infarctionInflammationMetastasisInfection
05
Safety considerations
Increased risk of bleedingThrombocytopenia
Beyond the preview
Go deeper on Platelet Glycoprotein Ib-IX-V Complex (GPIb-IX-V).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Platelet Glycoprotein Ib-IX-V Complex (GPIb-IX-V).