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Target intelligence / Profile preview
Platelet Glycoprotein Ib Receptor (GPIb)
- Target
- GPIb
- Molecular classification
- Receptor, Glycoprotein, Integrin-associated protein
01
Overview
The platelet glycoprotein Ib (GPIb) receptor is a critical component of the platelet membrane, essential for normal hemostasis and thrombosis. As part of the GPIb-IX-V complex, it mediates platelet adhesion to sites of vascular injury by binding von Willebrand factor (VWF), initiating platelet plug formation. The GPIb receptor also functions as a mechanoreceptor and regulates platelet activation through intracellular signaling pathways. Defects lead to bleeding disorders such as Bernard-Soulier syndrome, while gain-of-function mutations can cause platelet-type von Willebrand disease. GPIb is an important therapeutic target in antithrombotic drug development.
- Other names
- CD42GP IbGPIb-IX-V complex
02
Mechanism of action
Blocks VWF and thrombin interaction with GPIbα, inhibiting platelet adhesion and activation.
03
Biological functions
Platelet adhesionPlatelet activationMechanosensingSignal transductionHemostasis
04
Disease associations
Bernard-Soulier SyndromePlatelet-type von Willebrand DiseaseThrombosis
05
Safety considerations
Potential for bleeding complications with antagonists
06
Interacting drugs
Agkisacucetin
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