Target intelligence / Profile preview

Platelet Glycoprotein VI (None)

Target: None
Molecular classification: Type I transmembrane glycoprotein, Receptor

Overview

Platelet glycoprotein VI (GPVI) is a transmembrane glycoprotein primarily recognized as the major physiological receptor for collagen. It plays a central role in platelet activation and thrombus formation following vascular injury. Targeting GPVI offers promise as an anti-thrombotic strategy because its inhibition can prevent pathological thrombus formation while sparing normal hemostasis.

Mechanism of action

Inhibition of GPVI prevents platelet activation and thrombus formation.

Biological functions

Platelet adhesionPlatelet activationThrombus formationSignal transduction

Disease associations

ThrombosisArterial thrombosisVenous thrombosisThromboembolismThrombo-inflammationCancer-associated thrombosis

Safety considerations

Potential bleeding risk

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