Platelet glycoprotein VI receptor (GPVI)

The Platelet glycoprotein VI receptor (GPVI) is a transmembrane glycoprotein expressed exclusively on platelets and their precursor megakaryocytes. It is the primary receptor responsible for collagen-induced platelet activation, which is a key event in hemostasis and pathological thrombosis following vessel injury or rupture of atherosclerotic plaques. Structurally, GPVI is a member of the immunoglobulin superfamily, consisting of two extracellular Ig-like domains that bind collagen, a mucin-like stalk, a transmembrane region, and a cytoplasmic tail. GPVI signals via an associated Fc receptor γ-chain (FcRγ) that contains an immunoreceptor tyrosine-based activation motif (ITAM), activating a tyrosine kinase cascade leading to platelet activation and thrombus formation. It is recognized as a promising antithrombotic drug target since its inhibition reduces thrombus formation with relatively limited effects on baseline hemostasis compared to other antiplatelet therapies.

Other names

Glycoprotein VICollagen receptor GPVIGP6 (gene symbol)CD36L1 (less common)GPVI-Fc (therapeutic fusion protein)

Inhibition of collagen-induced platelet activation Blockade of GPVI-collagen binding Prevention of thrombus formation