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Platinum-DNA Adduct Formation
- Molecular classification
- DNA Modification, Drug-DNA Adduct
01
Overview
Platinum-DNA adduct formation refers to the covalent binding of platinum-based anticancer drugs (such as cisplatin, carboplatin, and oxaliplatin) to DNA. This process is central to the cytotoxic mechanism of these drugs, which are widely used in chemotherapy for various solid tumors. The platinum atom forms coordinate covalent bonds with nucleophilic sites on DNA bases—primarily the N7 position of guanine—resulting in a range of DNA lesions that disrupt cellular processes and trigger cell death.
02
Mechanism of action
Covalent binding to DNA, forming adducts that disrupt replication and transcription.
03
Biological functions
DNA damageReplication inhibitionTranscription inhibitionApoptosis induction
04
Disease associations
CancerDrug resistance
05
Safety considerations
ToxicityDrug resistance
06
Interacting drugs
Cisplatin
2 more in the full profile.
07
Biomarkers
Platinum-DNA adduct levelsERCC1 expression
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