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Platinum-DNA coordination (Pt-DNA)
- Target
- Pt-DNA
- Molecular classification
- Other
01
Overview
Platinum-DNA coordination involves the binding of platinum compounds to DNA, forming intrastrand and interstrand crosslinks. This interaction disrupts DNA replication and transcription, leading to cell death, particularly in cancer cells. Platinum-based drugs like cisplatin are used therapeutically to exploit this mechanism for cancer treatment[1][3][4].
- Other names
- Platinum-DNA adductsplatinum-DNA complexes
02
Mechanism of action
Intrastrand and interstrand DNA crosslinking leading to DNA damage and inhibition of DNA replication and transcription[4][5].
03
Biological functions
DNA replicationtranscriptioncell cycle regulationapoptosis
04
Disease associations
Cancer
05
Safety considerations
NephrotoxicityNeurotoxicityOtotoxicity
06
Interacting drugs
Cisplatin
2 more in the full profile.
07
Biomarkers
None specific to this target; however, platinum-DNA adducts can be used as markers of drug exposure.
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