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PLCXD2 antisense RNA 1 (PLCXD2-AS1)
- Target
- PLCXD2-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA
01
Overview
PLCXD2 antisense RNA 1 (PLCXD2-AS1) is a long non-coding RNA gene located on chromosome 3 (chr3:111675943-111677433, negative strand) and classified as an antisense lncRNA[3][5]. It regulates gene expression post-transcriptionally, mainly by acting as a competing endogenous RNA (ceRNA) that sponges microRNAs such as miR-378a-3p, thereby upregulating its sense gene, PLCXD2[1][4]. PLCXD2-AS1 has been shown to inhibit proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in gastric cancer cells through the miR-378a-3p/PLCXD2 regulatory axis. Although PLCXD2-AS1 participates in cancer biology, it is not itself considered a conventional therapeutic target such as an enzyme, receptor, or transporter[1][4][3][5]. No drugs are reported to directly target PLCXD2-AS1.
- Other names
- PLCXD2-AS1
02
Biological functions
Gene regulation (post-transcriptional regulation of PLCXD2)Competing endogenous RNA (ceRNA)
03
Disease associations
Cancer (notably gastric cancer)
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