Pleckstrin homology, MyTH4 and FERM domain containing H1 (PLEKHH1)

Pleckstrin homology, MyTH4 and FERM domain containing H1 (PLEKHH1) is a human protein-coding gene encoding a large, cytoskeletal and possibly membrane-associated protein characterized by multiple functional domains: two pleckstrin homology (PH) domains, one MyTH4 domain, and one FERM domain. Proteins with this combination of domains are typically involved in linking the cytoskeleton to cellular membranes, participating in phospholipid binding, scaffolding, and regulatory signal transduction events. PLEKHH1 is predicted to localize to the cytoskeleton and may have a role in cytoskeletal organization and/or intracellular signaling. However, specific physiological functions and disease associations remain largely uncharacterized in the literature. PLEKHH1 has not been established as a direct therapeutic target, nor are there any drugs targeting it or diseases where modulation of its activity has established therapeutic relevance. If more precise molecular or disease roles emerge in future research, these fields will require updating accordingly.

Other names

Pleckstrin homology domain-containing family H member 1KIAA1200PH domain-containing family H member 1PKHH1 (UniProt: Q9ULM0)pleckstrin homology domain containing, family H (with MyTH4 domain) member 1

Not applicable (no drugs known to target this protein directly; mechanisms would be speculative)