Pleckstrin homology and RhoGEF domain-containing G4B (PLEKHG4B)

Pleckstrin homology and RhoGEF domain-containing G4B (PLEKHG4B) is a large human protein that contains a pleckstrin homology domain and is predicted to act as a guanine nucleotide exchange factor (GEF). It is involved in signaling processes that regulate the activity of Rho family small GTPases, which play essential roles in cytoskeletal dynamics and cell signaling. PLEKHG4B is expressed in various human tissues and has been associated with cancer-relevant biological processes, but it is not a well-established drug target. Multiple datasets annotate its role in signal transduction, gene regulation, and its differential expression or mutation in certain cancer types[1][2][3][6].

Other names

ARHGEF48KIAA1909pleckstrin homology domain-containing family G member 4BPH domain-containing family G member 4Bpleckstrin homology domain containing, family G (with RhoGEF domain) member 4BPLEKHG4B