Pleckstrin homology and RhoGEF domain containing G7 (PLEKHG7)

PLEKHG7 encodes a protein with both pleckstrin homology (PH) and Dbl homology (DH) domains, characteristic of guanine-nucleotide exchange factors (“GEFs”) for Rho-family small GTPases[1][3][5][7][8]. It functions in cellular signal transduction by activating Rho proteins through exchange of GDP for GTP, thereby regulating processes such as cytoskeletal organization, cell morphology, and migration[1][3][7]. PLEKHG7 is implicated in tissue-specific functions including airway mucociliary epithelium regulation and has been associated with diseases such as pulp degeneration and pontocerebellar hypoplasia[1][7]. Molecularly, it belongs to the PH domain-containing family G and shares homology with PLEKHG5[1][3]. At present, there are no approved therapeutic agents directly targeting PLEKHG7 nor established clinical biomarkers, but its signaling role may make it of potential interest for disease modulation in cancer and degenerative conditions[1][7][10].

Other names

C12orf74FLJ46688Pleckstrin homology domain-containing family G member 7Chromosome 12 open reading frame 74PH domain-containing family G member 7AC115970.1pleckstrin homology domain containing, family G (with RhoGEF domain) member 7uncharacterized protein C12orf74