Pleckstrin homology domain containing A8 pseudogene 1 (PLEKHA8P1)

PLEKHA8P1 is a processed pseudogene located on chromosome 12 in humans. It is predicted—based on sequence similarity—to possess features similar to glycolipid transfer proteins and pleckstrin homology domains (which are relevant in lipid transport and signaling), but it does not express a functional mRNA or protein in tissues analyzed. Although older aliasing and computational annotations suggest potential functions similar to ceramide 1-phosphate binding or glycolipid transfer, there is no experimental evidence that PLEKHA8P1 is translated or functional. It is considered transcriptionally silent and remains distinct from its paralog PLEKHA8/FAPP2, which is a functional protein involved in glycolipid transfer and membrane transport[3][5]. References to "Putative protein PLEKHA9, putative glycolipid transfer protein" are misleading, as PLEKHA8P1 does not act as a receptor, enzyme, transporter, or therapeutic target.

Other names

PLEKHA8P1PLEKHA9Pleckstrin homology domain containing, family A member 8 pseudogene 1Pleckstrin homology domain-containing family A member 8 pseudogene 1Putative glycolipid transfer proteinFLJ14156Pleckstrin homology domain-containing family A (phosphoinositide binding specific) member 9

None known. Drug mechanisms discussed for related functional proteins (e.g., FAPP2, PLEKHA8) do not apply to PLEKHA8P1