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Target intelligence / Profile preview
Pleckstrin homology domain-containing family A member 2 (PLEKHA2)
- Target
- PLEKHA2
- Molecular classification
- Other, Pleckstrin homology (PH) domain-containing protein
01
Overview
Pleckstrin homology domain-containing family A member 2 (PLEKHA2) is a cytoplasmic protein that specifically binds phosphatidylinositol 3,4-bisphosphate at the plasma membrane, where it may recruit additional signaling proteins involved in intracellular signaling and cell-matrix adhesion[1][4][6]. It is implicated in pathways related to phosphoinositide metabolism and signal transduction, contributing to the positive regulation of cell-matrix adhesion. PLEKHA2 is broadly expressed and localizes to the cytoplasm and membrane. Mutations or altered function in PLEKHA2 have been associated with some hematological malignancies such as B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1, but it is not currently known to be directly targeted by any therapeutic drugs[1][6].
- Other names
- TAPP2TAPP-2Tandem PH domain-containing protein 2Pleckstrin homology domain containing A2PH domain-containing family A member 2PKHA2
02
Biological functions
Lipid binding (especially phosphatidylinositol 3,4-bisphosphate)Cell-matrix adhesionRecruitment of proteins to plasma membraneCell signaling
03
Disease associations
Cancer (notably B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1)
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