Pleckstrin homology domain-containing family B member 1 (PLEKHB1)

Pleckstrin homology domain-containing family B member 1 (PLEKHB1, also known as evectin-1 and various aliases) is a single-pass transmembrane protein containing an N-terminal pleckstrin homology domain, predominantly expressed in the mammalian brain and sensory tissues, especially the retina[1][3]. Its best-studied homologues and its vesicular localization suggest a role in intracellular membrane trafficking—specifically, protein transport involving recycling endosomes and the trans-Golgi network, possibly through binding to phosphatidylserine and unconventional myosins[1][2]. While its precise physiological function remains unclear, PLEKHB1 is implicated as a molecular regulator in neural health, with deregulation (especially decreased levels) linked experimentally to the onset of neurodegenerative changes in motor neurons in ALS mouse models[1]. It is not a well-established drug target, and no direct drugs or therapeutic mechanisms are currently identified.

Other names

Evectin-1KPL1PHR1PHRET1PH domain-containing protein in retina 1Pleckstrin homology domain retinal protein 1