Target intelligence / Profile preview

Pleckstrin homology domain-containing family B member 2 (PLEKHB2)

Target: PLEKHB2
Molecular classification: Pleckstrin homology domain-containing protein, Membrane-associated protein, Other

Overview

Pleckstrin homology domain-containing family B member 2 (PLEKHB2, also known as evectin-2) is a human protein comprising a pleckstrin homology (PH) domain that binds to specific phosphatidylinositol lipids in cellular membranes, facilitating membrane recruitment and signal transduction. It is predicted to be involved in the regulation of cell differentiation but is not considered a classical therapeutic target, with no documented drug interactions or roles as a disease biomarker.

Other names: evectin-2

Biological functions

Membrane recruitmentSignal transductionRegulation of cell differentiationPhosphatidylinositol lipid binding

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